Publications

  1. Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanovic N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI, Kopp JB, Skorecki K, Coresh J, Quyyumi AA, Sever S, Reiser J. “A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease.”. Nature medicine. 2017. PMID:28650456
  2. Holman KM, Puppala AK, Lee JW, Lee H, Simonovic M. “Insights into substrate promiscuity of human seryl-tRNA synthetase.”, RNA. 2017 Aug 14. PMID:28808125
  3. Lee H, Ren J, Nocadello S, Rice AJ, Ojeda I, Light S, Minasov G, Vargas J, Nagarathnam D, Anderson WF, Johnson ME. “Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus.” Antiviral Research, v. 139 pp. 49-58, 2017. PMID:28034741
  4. Rice AJ, Lei H, Santarsiero BD, Johnson ME. Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase). Bioorganic & medicinal chemistry. 2016. 24(19):4536-43. PMID: 27499369
  5. Han KY, Chang JH, Lee H, Azar DT. Proangiogenic Interactions of Vascular Endothelial MMP14 with VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis. Investigative ophthalmology & visual science. 2016. 57(7):3313-22. PMID:27327585
  6. Lei H, Jones C, Zhu T, Patel K, Wolf NM, Fung LW, Lee H, Johnson ME. Identification of B. anthracis N5-carboxyaminoimidazole ribonucleotide mutase (PurE) active site binding compounds via fragment library screening. Bioorganic & medicinal chemistry. 2016. PMID:26740153
  7. Han KY, Chang M, Ying HY, Lee H, Huang YH, Chang JH, Azar DT. Selective Binding of Endostatin Peptide 4 to Recombinant VEGF Receptor 3 In Vitro. Protein and peptide letters. 2015, 22(11):1025-30. PMID:26343062
  8. Jain AD, Potteti H, Richardson BG, Kingsley L, Luciano JP, Ryuzoji AF, Lee H, Krunic A, Mesecar AD, Reddy SP, Moore T. Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. European journal of medicinal chemistry. 2015, 103:252-68. PMID:26363505
  9. Han KY, Dugas-Ford J, Lee H, Chang JH, Azar DT. MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect. Investigative ophthalmology & visual science. 2015, 56(9):5450-6. PMID:26284550
  10. Lee H, Lei H, Santarsiero BD, Gatuz JL, Cao S, Rice AJ, Patel K, Szypulinski MZ, Ojeda I, Ghosh AK, Johnson ME. Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV. ACS chemical biology. 2015, 10(6), 1456-65. PMID:25746232
  11. Lee H, Mittal A, Patel K, Gatuz JL, Truong L, Torres J, Mulhearn DC, Johnson ME. Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings. Bioorganic & medicinal chemistry. 2014, 22(1):167-77. PMID:24332657
  12. Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J. Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation. Blood. 2013 May 9;121(19):3789-800, S1-15. PMID: 23460613
  13. Lee H, Zhu T, Patel K, Zhang YY, Truong L, Hevener KE, Gatuz JL, Subramanya G, Jeong H, Uprichard SL, Johnson ME. High-throughput screening (HTS) and hit validation to identify small molecule inhibitors with activity against NS3/4A proteases from multiple hepatitis C virus genotypes. PloS one. 2013, 8(10):e75144. PMID:24130685
  14. Rice AJ, Truong L, Johnson ME, Lee H, A colorimetric assay optimization for high-throughput screening of dihydroorotase by detecting ureido groups. Analytical biochemistry. 2013, 441(1):87-94. PMID:23769705
  15. Lee H, Cao S, Hevener KE, Truong L, Gatuz JL, Patel K, Ghosh AK, Johnson ME. Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications. ChemMedChem. 2013, 8(8):1361-72. PMID:23788528
  16. Tian Zhu, Hyun Lee, Hao Lei, Christopher Jones, Kavankumar Patel, Michael E. Johnson, Kirk E. Hevener, Fragment-based lead discovery using a multi-domain, parallel MM/PBSA simulation screening protocol, J Chem Inf Model., 53 (3), pp. 560–572, 2013.
  17. Chaudhuri R, Lee H, Truong L, Torres J, Patel K, Johnson ME. Identification of non-macrocyclic small molecule inhibitors against the NS3/4A serine protease of hepatitis C virus through in silico screening. Journal of chemical information and modeling. 2012, 52(8):2245-56. PMID:22697413
  18. Han KY, Azar DT, Sabri A, Lee H, Jain S, Lee BS, Chang JH. Characterization of the interaction between endostatin short peptide and VEGF receptor 3. Protein and peptide letters. 2012, 19(9):969-74. PMID:22512651
  19. Lee H, Torres J, Truong L, Chaudhuri R, Mittal A, Johnson ME. Reducing agents affect inhibitory activities of compounds: results from multiple drug targets. Analytical biochemistry. 2012, 423(1):46-53. PMID:22310499
  20. Lee H, Yuan C, Hammet A, Mahajan A, Chen ES, Wu MR, Su MI, Heierhorst J, Tsai MD. Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade. Molecular cell. 2008, 30(6):767-78. PMID:18570878.
  21. Qin D, Lee H, Yuan C, Ju Y, Tsai MD. Identification of potential binding sites for the FHA domain of human Chk2 by in vitro binding studies. Biochem. Biophys. Res. Commun. 2003, 311(4):803-8. PMID:14623252