Publications

Screening performed in the RRC HTS core:

  • Yao Y, Kong C, Yin L, Jain AD, Ratia K, Thatcher GR, Moore TW, Driver TG, Miller LW. Time-Gated Detection of Cystathionine γ-Lyase Activity and Inhibition with a Selective, Luminogenic Hydrogen Sulfide Sensor. Chemistry. 2017 Jan 18;23(4):752-756. PMID: 27734530
  • Park SK, Ratia K, Ba M, Valencik M, Liebman SW. Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs. Microb Cell. 2016 Jan 20;3(2):53-64. PMID:28357335
  • Lei H, Jones C, Zhu T, Patel K, Wolf NM, Fung LW, Lee H, Johnson ME. Identification of B. anthracis N(5)-carboxyaminoimidazole ribonucleotide mutase (PurE) active site binding compounds via fragment library screening. Bioorg Med Chem. 2016 Feb 15;24(4):596-605. PMID: 26740153
  • Aggarwal C, Jimenez JC, Lee H, Chlipala GE, Ratia K, Federle MJ. Identification of Quorum-Sensing Inhibitors Disrupting Signaling between Rgg and Short Hydrophobic Peptides in Streptococci. MBio. 2015 May 12;6(3). PMID:25968646
  • Ratia K, Light SH, Antanasijevic A, Anderson WF, Caffrey M, Lavie A. Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase. PLoS One. 2014 Feb 21;9(2). PMID: 24586713
  • Elshabrawy HA, Fan J, Haddad CS, Ratia K, Broder CC, Caffrey M, Prabhakar BS. Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay. J Virol. 2014 Apr;88(8):4353-65. PMID: 24501399
  • Wang J, Cheng H, Ratia K, Varhegyi E, Hendrickson WG, Li J, Rong L. A comparative high-throughput screening protocol to identify entry inhibitors of enveloped viruses. J Biomol Screen. 2014 Jan;19(1):100-7. PMID: 23821643
  • Lee H, Mittal A, Patel K, Gatuz JL, Truong L, Torres J, Mulhearn DC, Johnson ME. Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using both virtual and high-throughput screenings, Bioorganic & Med. Chemistry, 22, pp. 167-177, 2014.
  • Rice AJ, Truong L, Johnson ME, Lee H. A colorimetric assay optimization for high-throughput screening of dihydroorotase by detecting ureido groups, Analytical Biochemistry, 441 (1), pp. 87-94, 2013. PMID: 23769705
  • Lee H, Zhu T, Patel K, Zhang YY, Truong L, Hevener KE, Gatuz JL, Subramanya G, Jeong HY, Uprichard SL, Johnson ME. High-Throughput Screening (HTS) and Hit Validation to Identify Small Molecule Inhibitors with Activity against NS3/4A proteases from Multiple Hepatitis C Virus Genotypes, PLoS ONE, 8 (10): e75144, 2013.
  • Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation. J Med Chem. 2010 Jul 8;53(13):4968-79. PMID: 20527968