Genome Research Core

Genome Research Core is a combination of three sub-units - genomics, sequencing, and genome editing.

The Genome Editing (GE) sub-unit was formed in 2014, sprouting from the incorporation of CRISPR/Cas9 techniques into the lab of Dr. Brad Merrill. The power of CRISPR/Cas9 and its potential to redefine molecular genetic research inspired Dr. Merrill and the UIC Cancer Center to start up a new core with a three-pronged mission of 1) helping labs incorporate CRISPR/Cas9 genome editing into their existing research programs, 2) performing genome editing procedures to generate customized cell lines and mice, and 3) innovating new genome editing technology.

Since 2015, the GE has been run by Assistant Director Maureen Regan, who has a master’s degree in Chemistry and years of gene editing experience with technologies including ZFN, TALEN, & CRISPR platforms. She is responsible for all aspects of your project, from design to delivery.

 

The Sequencing (SQ) sub-unit serves the UIC scientific community as as well as external academic and non-academic researchers as a multi-faceted facility providing a broad range of services to investigators, including nucleic acid extraction, cell line authentication, Mycoplasma testing, quantitative PCR, capillary sequencing and next-generation sequencing (NGS). It also offers consultation for all projects, as needed. Sequencing also houses instrumentation for customer use (real-time PCR instruments, nucleic acid quantification devices, and acoustic shearing devices) and provides full service for nucleic acid extraction, quantitative PCR and analysis, daily capillary electrophoresis (Sanger) sequencing, and high-throughput NGS for analysis of DNA and RNA. It has particular expertise in the high-throughput microbiome studies and is highly responsive for time-sensitive sequencing projects.