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Study Design

The RIC provides advice and recommendations for many aspects of designing a high-throughput experiment, including:

  • Next-generation sequencing versus microarray platforms
  • NGS platforms (Illumina HiSeq, NextSeq, or MiSeq; PacBio or Nanopore)
  • Biological replicates and sequencing depth; power recommendations
  • Differences between library preparation options or microarray designs
  • Batch randomization

We highly recommend scheduling a meeting with the RIC when you are in the planning stages of your experiment, as there are often many options available, and the optimal one depends on your project's scope. These consultations are free of charge, and can be arranged by contacting us. It is often also valuable to include members of the Sequencing Core and/or Genomics Core in these consultations.